The Bioinformatics Core Facility is built upon the infrastructure of Nebraska Center for Virology (NCV). The facility is funded from NCV’s COBRE. The objective of the core facility is to support biological research at NCV, which includes biological communities in University of Nebraska-Lincoln, University of Nebraska Medical Center, and Creighton University. We operate under both collaborative and fee-based models, and work with researchers and investigators to come up with a feasible plan that meets their needs and fits their budget.The core facility is equipped with high-performance computers, bioinformatics related software, biological databases, and data storage. We provide bioinformatics and computational services in virology, molecular biology, genomics, proteomics, next generation high throughput sequencing, and other biological related fields. For special requirements, we can design and develop new algorithms, and implement programs and customize data processing pipelines to unveil invaluable information buried in vast amount of biological data to achieve research goals. The core Promotes education in bioinformatics to students and researchers, develops and delivers training material, including workshops that facilitate practical application of the bioinformatics knowledge by students, postdoctoral fellows, and faculties in NCV community.